Boehringer Ingelheim Frontline Plus Tick & Flea Spot On for Large Dogs (20kg to 40kg)

Boehringer Ingelheim Frontline Plus Spot On for Large Dogs (20kg to 40kg) - Monthly Flea and Tick Protection for Your Large Dog

Large breed dogs face a bigger tick challenge than most pet parents realise. More surface area means more places for ticks to hide and feed - and in India's warm, humid climate, tick season is effectively year-round. A single missed month of protection can mean a full-blown infestation before you even notice the signs.

The Boehringer Ingelheim Frontline Plus Spot On for Large Dogs is a once-a-month topical flea and tick treatment formulated specifically for dogs between 20 kg and 40 kg. One pipette - containing the volume matched to this weight range - delivers 30 days of continuous protection against fleas, ticks, chewing lice, and the reinfestation that comes from flea eggs and larvae. Waterproof. Fast-acting. Trusted by vets globally for decades.

Manufactured by Boehringer Ingelheim Animal Health France SCS and marketed in India by Boehringer Ingelheim India Pvt. Ltd.

Each 2.68 ml pipette contains: Fipronil (9.8% w/v) and (S)-Methoprene (8.8% w/v).

What Are the Uses and Benefits of Frontline Plus Spot On for Large Dogs?

• Frontline Plus covers every stage of a flea and tick infestation - not just what you can see right now.
• Adult fleas are killed within 24 hours of contact with the treated coat. Adult ticks and chewing lice are killed within 48 hours. Your dog doesn't need to be bitten for the treatment to work - fleas and ticks die on contact with the treated skin and coat.
• Flea eggs and larvae are eliminated by (S)-Methoprene, the second active ingredient. This is the part that most single-ingredient tick products skip. Flea eggs laid by adult fleas that come into contact with a treated dog are sterilised - they cannot hatch. Larvae already in the environment that come into contact with the treated coat also die. This breaks the flea life cycle, preventing the wave of reinfestation that typically follows an adult flea kill.
• Flea Allergy Dermatitis (FAD) - a skin reaction caused by flea saliva - is one of the most common dermatological conditions in Indian dogs. By eliminating fleas before they can bite, Frontline Plus removes the trigger entirely. For more on skin allergies and what flea bites can do, the blog on understanding skin allergies and atopic dermatitis in pets is a helpful read.
• Chewing lice infestations are also covered - the same 48-hour kill applies.
• Tick-borne diseases - including Ehrlichiosis, Babesiosis, and Anaplasmosis - pose a real threat to Indian dogs, particularly those who spend time outdoors. By eliminating ticks within 48 hours of contact, Frontline Plus significantly reduces the window in which disease transmission can occur. For more on tick fever, the blog on tick fever in dogs - symptoms, treatment and prevention explains the risks clearly.
• The protection is waterproof - it holds up through rain, swimming, and baths after the initial 48-hour settling period.

What Are the Possible Side Effects?

• Frontline Plus has one of the most established safety profiles of any flea and tick treatment available - billions of doses have been administered globally since the 1990s, and serious side effects are rare.
• The application site may appear slightly wet, oily, or clumped for up to 24 hours after application. This is completely normal as the product absorbs into the skin oils and is nothing to worry about.
• Some dogs may experience mild, temporary skin irritation or redness at the spot where the product was applied. This usually resolves within a day or two without any intervention.
• If your dog manages to lick the application site before it dries, they may drool briefly or show mild oral discomfort - this is related to the solvent in the formula rather than the active ingredients and passes quickly. Apply correctly at the base of the neck where they cannot reach to prevent this.
• In rare cases, reversible neurological signs - such as brief hypersensitivity to touch or mild depression - have been observed. These resolve on their own without treatment.
• Allergic reactions to fipronil or (S)-Methoprene are possible but extremely rare. If you notice facial swelling, difficulty breathing, or severe lethargy after application, contact your vet immediately.

How Should You Apply Frontline Plus to Your Large Dog?

• Applying the spot on correctly is what makes it effective. The entire contents of one pipette should be applied in a single session - do not split it or save part of it for later.
• Hold the pipette upright and snap off the cap. Part the coat on the back of your dog's neck, right at the base between the shoulder blades - the one place your dog cannot twist around to lick. Place the tip of the pipette directly on the exposed skin and squeeze the entire 2.68 ml out in a single spot.
• Do not rub it in. Let it spread naturally through the skin oils over the next 24 hours.
• Do not bathe your dog or let them swim for 48 hours before and after application. The product needs this settling window to properly absorb and distribute through the coat.
• Apply once every 30 days for continuous, uninterrupted protection. Set a phone reminder the moment you finish each application for the same date next month.
• For thick-coated large breeds - German Shepherds, Golden Retrievers, Labradors - make sure the pipette contents reach the skin and not just the outer coat. Part the fur firmly to expose skin before applying.

How Does Frontline Plus Work?

• Frontline Plus works through two active ingredients with different jobs - covering both present parasites and the next generation.
• Fipronil is the parasite killer. It blocks GABA-gated chloride ion channels in the nervous systems of fleas, ticks, and lice - causing uncontrolled nervous system activity, paralysis, and death. Fipronil is stored in the skin's natural oils and hair follicles after application - not absorbed into the bloodstream. It spreads across the entire body surface within 24 hours through this oil-distribution mechanism, which is also what makes it water-resistant. Fleas are killed within 24 hours; ticks and lice within 48 hours.
• (S)-Methoprene handles the flea life cycle. It's an Insect Growth Regulator that mimics a natural juvenile hormone in flea development. When flea eggs or larvae come into contact with (S)-Methoprene on a treated dog's coat, their development is disrupted - they cannot mature into adults and reproduce. This prevents the cycle of reinfestation that affects so many pet parents who clear an active flea infestation only to see it return weeks later.
• Together, these two ingredients approach the flea problem from two directions - killing adults and preventing the next generation from ever developing.

What Safety Advice Should You Know Before Using Frontline Plus?

• This pipette is specifically for dogs between 20 kg and 40 kg. Do not use a pipette formulated for a smaller weight range on a large dog - underdosing reduces effectiveness. Do not use a pipette from a larger weight range either - always match the pipette to your dog's current weight.
• Never use a dog formulation on a cat. The concentration of active ingredients in dog pipettes is far higher than in cat formulations and can cause serious harm to cats.
• Do not use on puppies under 8 weeks of age.
• Do not use on sick, feverish, or convalescing dogs without vet clearance.
• Do not apply simultaneously with other topical flea or tick treatments.
• Keep children away from the application site until it has fully dried. Wash hands thoroughly after applying.
• Fipronil and (S)-Methoprene can be harmful to aquatic organisms. Do not wash the product or the pipette into drains, ponds, or waterways.
• Safe for use in pregnant and lactating females. Store below 30°C in the original packaging, away from direct sunlight. Keep out of reach of children.

What Should You Do If You Miss a Dose?

• If you miss a monthly application, apply the pipette as soon as you remember and reset your reminder from that new date. Do not apply two pipettes at once to make up for the missed month.
• During any gap in coverage - particularly in monsoon and post-monsoon months when tick populations peak - check your dog's coat regularly, especially around the neck, ears, between the toes, and under the collar. Resume Frontline Plus as soon as possible if you find ticks during a coverage gap.
• Consistency every 30 days is what makes a preventive flea and tick routine actually preventive - not reactive.

What Are All the Substitutes for Frontline Plus for Large Dogs?

If Frontline Plus for large dogs is unavailable or your vet recommends an alternative, here are other flea and tick treatments for large dogs available on Supertails:

What Are Some Quick Tips for Getting the Most Out of Frontline Plus?

• For thick-coated large breeds, spend a few extra seconds parting the fur at the application site to make sure the pipette tip is actually touching skin before you squeeze. Depositing the product on top of a dense coat significantly reduces how well it absorbs and spreads.
• Mark the application date somewhere you'll see it - on your phone calendar, on the fridge, wherever works for you. With a 30-day cycle, it's easy to lose track on busy months.
• Don't bathe your dog in the 48 hours before or after application. For dogs who get bathed frequently or swim regularly, time their bath to fall at least 48 hours before the next application is due - and use a gentle, non-stripping shampoo that doesn't break down the skin oils the product relies on for distribution.
• If you have multiple dogs in the household, treat all of them on the same day. Fleas move between animals freely - treating one and not the others leaves a reservoir for reinfestation within days.
• Treating your dog handles the parasites living on them - but fleas spend most of their life cycle off the pet, in carpets, bedding, and furniture. For a significant or recurring flea infestation, vacuum regularly and wash your dog's bedding on a hot cycle. The blog on how to get rid of fleas and ticks from dogs and cats covers the environmental side of flea control clearly.

Vets Also Recommend...

• The full dog fleas and ticks collection brings together all vet-approved flea and tick treatments - spot-ons, oral tablets, shampoos, and sprays - so you can compare options and build the right protection plan for your dog's lifestyle and exposure level.
• For the other Frontline Plus variants across dog sizes, explore the full pharmacy tick and flea control for dogs collection - from small breeds through to XL - all available on Supertails.
• For large breeds who also need deworming alongside tick and flea protection, the dog dewormer collection has vet-approved options to use alongside your monthly spot-on.
• If your dog has had skin reactions to flea bites or is managing Flea Allergy Dermatitis, the dog skin and coat care collection has medicated shampoos and skin recovery products to support healing alongside the preventive treatment.
• And if you'd like a vet to advise on the best complete parasite prevention plan for your specific dog's breed, weight, lifestyle, and health history - Supertails' online vet consultation service is available whenever you need it.

Disclaimer: Supertails' sole intention is to ensure that its consumers get information that is expert-reviewed, accurate, and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Your Large Dog Deserves Real Protection - Give Them a Tick-Free Month, Every Month

Large dogs don't get a pass on fleas and ticks - if anything, their size and outdoor lifestyle put them at higher risk. The Boehringer Ingelheim Frontline Plus Spot On for Large Dogs is one of the most trusted, vet-recommended monthly flea and tick treatments available in India - built for dogs between 20 and 40 kg.

One pipette. One application. Thirty days of real, continuous protection. Shop the Frontline Plus Spot On for Large Dogs on Supertails and get it delivered to your door.

FAQs

My dog is right at the border between weight ranges - 20 kg exactly. Which variant should I use?

The large dog pipette covers dogs from 20 kg upward, so a 20 kg dog falls into this range. If your dog is right at the boundary, confirm with your vet - they'll advise based on your dog's build and body condition, not just the number on the scale. When in doubt, always use the pipette calibrated for your dog's actual weight rather than estimating.

How quickly does Frontline Plus start working after application?

Fleas are killed within 24 hours of contact with the treated coat. Ticks and chewing lice are killed within 48 hours. The solution spreads across your dog's entire body surface through the skin's natural oils within 24 hours of application - so full coverage is established quickly after the first dose.

My dog gets bathed every week. Will Frontline Plus still work?

Frontline Plus is waterproof after the initial 48-hour settling period, but frequent bathing - particularly with harsh shampoos - can gradually reduce the skin oils through which the product distributes. For dogs bathed very frequently, the effective protection window may be shorter than 30 days. Time baths to fall at least 48 hours before the next application is due, and use a mild, gentle shampoo. Your vet may also suggest an oral tick treatment as an alternative for dogs who are bathed or swim very frequently.

Can I use this spot-on alongside a tick shampoo on the same day?

No - do not use any other topical flea or tick product on the same day as applying Frontline Plus. This includes medicated shampoos, tick sprays, and powders. Using multiple topical treatments simultaneously increases the risk of skin reactions without adding meaningful additional protection. If you want to use a tick shampoo, time it at least 48 hours before or after applying the spot-on.

My dog is pregnant. Is Frontline Plus safe to use?

Yes - Frontline Plus is safe for use in pregnant and lactating females. That said, it's always good practice to inform your vet about any product you're using during pregnancy, so they have a complete picture of your dog's health management.

Should I be worried if the application site looks oily or clumped after applying?

No - this is completely normal and expected. The product is stored in a liquid carrier that absorbs into the skin oils, and the coat may look wet, oily, or slightly matted at the application site for up to 24 hours. It resolves on its own as the product absorbs and distributes. Do not wash it off or try to dry it with a towel - this removes the product before it has been absorbed.

Can I use this pipette on my cat?

No - never use a dog-formulated pipette on a cat. The concentration of active ingredients in dog pipettes is significantly higher than in cat formulations and can cause serious harm to cats. Frontline Plus has a separate cat-specific pipette for feline use.

What happens if I apply this pipette to a dog below 20 kg?

This would be an overdose - the 2.68 ml volume and corresponding dose of active ingredients is calibrated for dogs in the 20-40 kg range. If you accidentally apply it to a smaller dog, wash the application site immediately with mild shampoo and water and contact your vet.