Boehringer Ingelheim Frontline Plus Tick & Flea Spot On for XLarge Dogs (40kg to 60kg)

Boehringer Ingelheim Frontline Plus Spot On for XLarge Dogs (40kg to 60kg) - Monthly Flea and Tick Protection for Your Big Dog

Large and giant breed dogs face a bigger tick challenge than most pet parents realise. More surface area means more places for ticks to hide and feed - and in India's warm, humid climate, tick season is effectively year-round. A single missed month of protection can mean a full-blown infestation before you even notice the signs.

The Boehringer Ingelheim Frontline Plus Spot On for XLarge Dogs is a once-a-month topical flea and tick treatment formulated specifically for dogs between 40 kg and 60 kg. One pipette - containing a higher volume than smaller-breed variants - delivers 30 days of continuous protection against fleas, ticks, chewing lice, and the reinfestation that comes from flea eggs and larvae. Waterproof. Fast-acting. Trusted by vets globally for decades.

Manufactured by Boehringer Ingelheim Animal Health France SCS and marketed in India by Boehringer Ingelheim India Pvt. Ltd.

Each 4.02 ml pipette contains: Fipronil (9.8% w/v) and (S)-Methoprene (8.8% w/v).

What Are the Uses and Benefits of Frontline Plus Spot On for XLarge Dogs?

• Frontline Plus for XL dogs covers every stage of a flea and tick infestation - not just what you can see right now.
• Adult fleas are killed within 24 hours of contact with the treated coat. Adult ticks and chewing lice are killed within 48 hours. Your dog doesn't need to be bitten for the treatment to work - fleas and ticks die on contact with the treated skin and coat.
• Flea eggs and larvae are eliminated by (S)-Methoprene, the second active ingredient. This is the part that most single-ingredient tick products skip. Flea eggs laid by adult fleas that come into contact with a treated dog are sterilised - they cannot hatch. Larvae already in the environment that come into contact with the treated coat also die. This breaks the flea life cycle, preventing the wave of reinfestation that typically follows an adult flea kill.
• Flea Allergy Dermatitis (FAD) - a skin reaction caused by flea saliva - is one of the most common dermatological conditions in Indian dogs. By eliminating the fleas before they can bite, Frontline Plus removes the trigger entirely, bringing real relief to dogs with this condition. For more on skin allergies and what flea bites can do, the blog on understanding skin allergies and atopic dermatitis in pets is a helpful read.
• Chewing lice infestations are also covered - the same 48-hour kill applies.
• Tick-borne diseases - including Ehrlichiosis, Babesiosis, and Anaplasmosis - pose a real threat to Indian dogs, particularly large breeds who spend time outdoors. By eliminating ticks within 48 hours of contact, Frontline Plus significantly reduces the window in which disease transmission can occur. For more on tick fever, the blog on tick fever in dogs - symptoms, treatment and prevention explains the risks clearly.
• The protection is waterproof - it holds up through rain, swimming, and baths after the initial 48-hour settling period.

What Are the Possible Side Effects?

• Frontline Plus has one of the most established safety profiles of any flea and tick treatment available - billions of doses have been administered globally since the 1990s, and serious side effects are rare.
• The application site may appear slightly wet, oily, or clumped for up to 24 hours after application. This is completely normal as the product absorbs into the skin oils and is nothing to worry about.
• Some dogs may experience mild, temporary skin irritation or redness at the spot where the product was applied. This usually resolves within a day or two without any intervention.
• If your dog manages to lick the application site before it dries, they may drool briefly or show mild oral discomfort - this is related to the solvent in the formula rather than the active ingredients and passes quickly. It's not dangerous but worth preventing by applying correctly at the base of the neck where they cannot reach.
• In rare cases, reversible neurological signs - such as brief hypersensitivity to touch or mild depression - have been observed. These resolve on their own without treatment.
• Allergic reactions to fipronil or (S)-Methoprene are possible but extremely rare. If you notice facial swelling, difficulty breathing, or severe lethargy after application, contact your vet immediately.

How Should You Apply Frontline Plus to Your XLarge Dog?

• Applying the spot-on correctly is what makes it effective. The entire contents of one pipette should be applied in a single session - do not split it or save part of it for later.
• Hold the pipette upright and snap off the cap. Part the coat on the back of your dog's neck, right at the base between the shoulder blades - the one place your dog cannot twist around to lick. Place the tip of the pipette directly on the exposed skin and squeeze the entire 4.02 ml out. For very large dogs, you can spread the contents across 3-4 spots along the back - your vet will advise if this is appropriate for your dog's size.
• Do not rub it in. Let it spread naturally through the skin oils over the next 24 hours.
• Do not bathe your dog or let them swim for 48 hours before and after application. The product needs this settling window to properly absorb and distribute through the coat.
• Apply once every 30 days for continuous, uninterrupted protection. Set a phone reminder the moment you finish each application for the same date next month.
• For large, thick-coated dogs - German Shepherds, Golden Retrievers, Huskies - make sure the pipette contents reach the skin and not just the outer coat. Part the fur firmly to expose skin before applying.

How Does Frontline Plus Work?

• Frontline Plus works through two active ingredients with different jobs - covering both present parasites and the next generation.
• Fipronil is the parasite killer. It works by blocking GABA-gated chloride ion channels in the nervous systems of fleas, ticks, and lice. Without these channels functioning, the parasite's nerve signals go haywire - causing uncontrolled nervous system activity, paralysis, and death. Crucially, Fipronil is stored in the skin's natural oils and hair follicles after application - not absorbed into the bloodstream. It spreads across the entire body surface within 24 hours through this oil-distribution mechanism, which is also what makes it water-resistant. Fleas are killed within 24 hours; ticks and lice within 48 hours.
• (S)-Methoprene handles the flea life cycle. It's an Insect Growth Regulator - a compound that mimics a natural juvenile hormone in flea development. When flea eggs or larvae come into contact with (S)-Methoprene on a treated dog's coat, their development is disrupted - they cannot mature into adults and reproduce. This prevents the cycle of reinfestation that affects so many pet parents who clear an active flea infestation only to see it return weeks later from eggs and larvae in the environment.
• Together, these two ingredients approach the flea problem from two directions - killing adults and preventing the next generation from ever developing.

What Safety Advice Should You Know Before Using Frontline Plus?

• This pipette is specifically for dogs between 40 kg and 60 kg. Do not use a pipette formulated for a smaller weight range on an XL dog - underdosing reduces effectiveness. Do not use more than one pipette in a single application without vet guidance.
• Never use a dog formulation on a cat. The concentration of active ingredients in dog pipettes is far higher than in cat formulations and can cause serious harm to cats.
• Do not use on puppies under 8 weeks of age.
• Do not use on sick, feverish, or convalescing dogs without vet clearance.
• Do not apply simultaneously with other topical flea or tick treatments - this increases the risk of adverse reactions without adding meaningful protection benefit.
• If your dog is on any medications, let your vet know before starting Frontline Plus - while interactions are uncommon, it's always worth confirming.
• Keep children away from the application site until it has fully dried. Wash hands thoroughly after applying.
• Fipronil and (S)-Methoprene can be harmful to aquatic organisms. Do not wash the product or the pipette into drains, ponds, or waterways.
• Safe for use in pregnant and lactating females.
• Store below 30°C in the original packaging, away from direct sunlight. Keep out of reach of children.

What Should You Do If You Miss a Dose?

• If you miss a monthly application, apply the Frontline Plus pipette as soon as you remember and reset your monthly reminder from that new date. Do not apply two pipettes at once to make up for the missed month.
• During any gap in coverage - particularly in monsoon and post-monsoon months when tick populations peak - check your dog's coat regularly by running your fingers through the fur, particularly around the neck, ears, between the toes, and under the collar. If you find ticks during a coverage gap, remove them carefully and resume Frontline Plus application as soon as possible.
• Consistency every 30 days is what makes a preventive flea and tick routine actually preventive - not reactive.

What Are All the Substitutes for Frontline Plus XLarge Dogs?

If Frontline Plus XL is unavailable or your vet recommends an alternative, here are other flea and tick treatments for large and XL dogs available on Supertails:

What Are Some Quick Tips for Getting the Most Out of Frontline Plus?

• For thick-coated large breeds, spend a few extra seconds parting the fur at the application site to make sure the pipette tip is actually touching skin before you squeeze. Depositing the product on top of a dense coat significantly reduces how well it absorbs and spreads.
• Mark the application date somewhere you'll see it - on your phone calendar, on the fridge, wherever works for you. With a 30-day cycle, it's easy to lose track, especially on busy months.
• Don't bathe your dog in the 48 hours before or after application. For dogs who get bathed frequently or swim regularly, time their bath to fall at least 48 hours before the next application is due - and switch to a gentle, non-stripping shampoo that doesn't break down the skin oils the product relies on for distribution.
• If you have multiple dogs in the household, treat all of them on the same day. Fleas move between animals freely - treating one and not the others leaves a reservoir for reinfestation within days.
• Treating your dog handles the parasites living on them - but fleas spend most of their life cycle off the pet, in carpets, bedding, and furniture. For a significant or recurring flea infestation, vacuum regularly, wash your dog's bedding on a hot cycle, and consider an environmental spray. The blog on how to get rid of fleas and ticks from dogs and cats covers the environmental side of flea control clearly.

What Do Vets Also Recommend?

• The full dog fleas and ticks collection brings together all vet-approved flea and tick treatments - spot-ons, oral tablets, shampoos, and sprays - so you can compare options and build the right protection plan for your dog's lifestyle and exposure level.
• For the other Frontline Plus variants across dog sizes, explore the full Frontline Plus range for dogs - from small breeds through to XL - all available on Supertails.
• For large breeds who also need deworming alongside tick and flea protection, the dog dewormer collection has vet-approved options to use alongside your monthly spot-on.
• If your large breed dog has had skin reactions to flea bites or is managing Flea Allergy Dermatitis, the dog skin and coat care collection has medicated shampoos and skin recovery products to support healing alongside the preventive treatment.
• And if you'd like a vet to advise on the best complete parasite prevention plan for your specific dog's breed, weight, lifestyle, and health history - Supertails' online vet consultation service is available whenever you need it.

Disclaimer: Supertails' sole intention is to ensure that its consumers get information that is expert-reviewed, accurate, and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Your Big Dog Deserves Big Protection - Give Them a Tick-Free Month, Every Month

Large dogs don't get a pass on fleas and ticks - if anything, their size and outdoor lifestyle put them at higher risk. The Boehringer Ingelheim Frontline Plus Spot On for XLarge Dogs is one of the most trusted, vet-recommended monthly flea and tick treatments available in India - built for the specific weight and coat challenges of dogs between 40 and 60 kg.

One pipette. One application. Thirty days of real, continuous protection. Shop the Frontline Plus Spot On for XLarge Dogs on Supertails and get it delivered to your door.

FAQs

Is this pipette suitable for dogs above 60 kg?

No - this pipette is formulated for dogs between 40 kg and 60 kg. For dogs above 60 kg, consult your vet. They may recommend using this pipette plus an additional partial dose, or combining pipettes from different weight ranges to achieve adequate coverage for your dog's body weight. Never exceed the total recommended dose without veterinary guidance.

How quickly does Frontline Plus start working after application?

Fleas are killed within 24 hours of contact with the treated coat. Ticks and chewing lice are killed within 48 hours. The solution spreads across your dog's entire body surface through the skin's natural oils within 24 hours of application - so full coverage is established quickly after the first dose.

My large breed dog gets bathed every week. Will Frontline Plus still work?

Frontline Plus is waterproof after the initial 48-hour settling period, but frequent bathing - particularly with harsh shampoos - can gradually strip the skin oils that the product distributes through. For dogs bathed very frequently, the effective protection window may be shorter than 30 days. Time baths to fall at least 48 hours before the next application is due, and use a mild, gentle shampoo. Your vet may also suggest an oral tick treatment as an alternative for dogs who are bathed or swim very frequently.

Can I use this spot on alongside a tick and flea shampoo on the same day?

No - do not use any other topical flea or tick product on the same day as applying Frontline Plus. This includes medicated shampoos, tick sprays, and powders. Using multiple topical treatments simultaneously increases the risk of skin reactions and doesn't provide additional protection. If you want to use a tick shampoo, time it at least 48 hours before or after applying the spot-on.

My dog is pregnant. Is Frontline Plus safe to use?

Yes - Frontline Plus is safe for use in pregnant and lactating females. This is confirmed in the product's clinical data. That said, it's always good practice to inform your vet about any product you're using during pregnancy, so they have a complete picture of your dog's health management.

Do I need to apply the pipette in multiple spots for my XL dog?

Officially, the product is designed to be applied in a single spot at the base of the neck between the shoulder blades. For very large dogs with thick, dense coats, some vets recommend spreading the contents across 2-3 spots along the back to ensure better skin absorption. Check with your vet for specific advice for your dog's breed and coat type - particularly relevant for dogs like Huskies, Saint Bernards, or Bernese Mountain Dogs with very thick undercoats.

Why is there a separate pipette for XL dogs rather than just using more of a smaller one?

Each weight-range variant contains a specific volume of the solution calibrated to provide the correct dose of fipronil and (S)-Methoprene per kg of body weight for that weight category. Simply using multiple small-breed pipettes would alter the ratio of active ingredients and volume in ways that are not tested or recommended. Always use the pipette specifically designed for your dog's weight range.

What should I do if I accidentally apply the pipette to the wrong dog?

If you applied an XL dog pipette to a small or medium dog - this is an overdose situation. Wash the application site immediately and thoroughly with mild shampoo and water, and contact your vet right away. Symptoms of overdose can include skin irritation, excessive salivation if licked, and in significant overdose, neurological signs. Prompt washing and vet contact are the right response.